Cracked nipples in breastfeeding mothers . Hepatitis B and C Infections Breastfeeding CDC
Lactation of pigs Lactation describes the secretion of milk from the mammary glands and the period of time that a mother lactates to feed her young. The process can occur with all post- pregnancy female mammals, although it predates mammals.  In humans the process of feeding milk is also called breastfeeding or nursing.
In most species, milk comes out of the mother s nipples; however, the monotremes, egg-laying mammals, lack nipples and release milk through ducts in the abdomen. In only one species of mammal, the Dayak fruit bat, is milk production a normal male function. Galactopoiesis is the maintenance of milk production. This stage requires prolactin. Oxytocin is critical for the milk let-down reflex in response to suckling.
Newborn infants often produce some witch s milk. Galactorrhea is milk production unrelated to nursing, it can occur in males and females of many mammal species as result of hormonal imbalances or unusual physiological stimuli. Contents 1 Purpose 2 Human 2.1 Hormonal influences 2.1.1 Secretory differentiation 2.1.2 Secretory activation 2.1.3 Autocrine control - Galactapoiesis 2.2 Milk ejection reflex 2.2.1 Milk ejection reflex mechanism 2.3 Afterpains 3 Without pregnancy, induced lactation, relactation 4 Evolution 5 See also 6 References 7 External links Purpose [ edit ] The chief function of lactation is to provide nutrition and immune protection to the young after birth. In almost all mammals, lactation induces a period of infertility, which serves to provide the optimal birth spacing for survival of the offspring.  Human [ edit ] When the baby sucks its mother s breast, a hormone called oxytocin compels the milk to flow from the alveoli, through the ducts (milk canals) into the sacs (milk pools) behind the areola and then into the baby s mouth Leaking milk from a human breast.
Hormonal influences [ edit ] From the twenty-fourth week of pregnancy (the second and third trimesters), a woman s body produces hormones that stimulate the growth of the milk duct system in the breasts: Progesterone influences the growth in size of alveoli and lobes; high levels of progesterone inhibit lactation before birth. Progesterone levels drop after birth; this triggers the onset of copious milk production.  Estrogen stimulates the milk duct system to grow and differentiate.
Like progesterone, high levels of estrogen also inhibit lactation. Estrogen levels also drop at delivery and remain low for the first several months of breastfeeding.  Breastfeeding mothers should avoid estrogen-based birth control methods, as a spike in estrogen levels may reduce a mother s milk supply. Prolactin contributes to the increased growth and differentiation of the alveoli, and also influences differentiation of ductal structures. High levels of prolactin during pregnancy and breastfeeding also increase insulin resistance, increase growth factor levels (IGF-1) and modify lipid metabolism in preparation for breastfeeding.
During lactation, prolactin is the main factor maintaining tight junctions of the ductal epithelium and regulating milk production through osmotic balance. Human placental lactogen (HPL) – from the second month of pregnancy, the placenta releases large amounts of HPL. This hormone is closely associated with prolactin and appears to be instrumental in breast, nipple, and areola growth before birth. Follicle stimulating hormone (FSH), luteinizing hormone (LH), and human chorionic gonadotropin (hCG), through control of estrogen and progesterone production, and also, by extension, prolactin and growth hormone production, are essential. Growth hormone (GH) is structurally very similar to prolactin and independently contributes to its galactopoiesis. Adrenocorticotropic hormone (ACTH) and glucocorticoids such as cortisol have an important lactation inducing function in several animal species, including humans.
Glucocorticoids play a complex regulating role in the maintenance of tight junctions. Thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH) are very important galactopoietic hormones whose levels are naturally increased during pregnancy. Oxytocin contracts the smooth muscle of the uterus during and after birth, and during orgasm(s).
After birth, oxytocin contracts the smooth muscle layer of band-like cells surrounding the alveoli to squeeze the newly produced milk into the duct system. Oxytocin is necessary for the milk ejection reflex, or let-down, in response to suckling, to occur. By the fifth or sixth month of pregnancy, the breasts are ready to produce milk. It is also possible to induce lactation without pregnancy. Breastfeeding of an older child Secretory differentiation [ edit ] During the latter part of pregnancy, the woman s breasts enter into the Secretory Differentiation stage. This is when the breasts make colostrum (see below), a thick, sometimes yellowish fluid.
At this stage, high levels of progesterone inhibit most milk production. It is not a medical concern if a pregnant woman leaks any colostrum before her baby s birth, nor is it an indication of future milk production. Secretory activation [ edit ] At birth, prolactin levels remain high, while the delivery of the placenta results in a sudden drop in progesterone, estrogen, and HPL levels. This abrupt withdrawal of progesterone in the presence of high prolactin levels stimulates the copious milk production of Secretory Activation.
When the breast is stimulated, prolactin levels in the blood rise, peak in about 45 minutes, and return to the pre-breastfeeding state about three hours later. The release of prolactin triggers the cells in the alveoli to make milk. Prolactin also transfers to the breast milk. Some research indicates that prolactin in milk is greater at times of higher milk production, and lower when breasts are fuller, and that the highest levels tend to occur between 2 a.m.
and 6 a.m.  Other hormones notably insulin, thyroxine, and cortisol are also involved, but their roles are not yet well understood. Although biochemical markers indicate that Secretory Activation begins about 30–40 hours after birth, mothers do not typically begin feeling increased breast fullness (the sensation of milk coming in the breast ) until 50–73 hours (2–3 days) after birth. Colostrum is the first milk a breastfed baby receives. It contains higher amounts of white blood cells and antibodies than mature milk, and is especially high in immunoglobulin A (IgA), which coats the lining of the baby s immature intestines, and helps to prevent pathogens from invading the baby s system.
Secretory IgA also helps prevent food allergies.  Over the first two weeks after the birth, colostrum production slowly gives way to mature breast milk.  Autocrine control - Galactapoiesis [ edit ] The hormonal endocrine control system drives milk production during pregnancy and the first few days after the birth.
When the milk supply is more firmly established, autocrine (or local) control system begins. During this stage, the more that milk is removed from the breasts, the more the breast will produce milk.   Research also suggests that draining the breasts more fully also increases the rate of milk production.  Thus the milk supply is strongly influenced by how often the baby feeds and how well it is able to transfer milk from the breast. Low supply can often be traced to: not feeding or pumping often enough inability of the infant to transfer milk effectively caused by, among other things: jaw or mouth structure deficits poor latching technique rare maternal endocrine disorders hypoplastic breast tissue inadequate calorie intake or malnutrition of the mother Milk ejection reflex [ edit ] This is the mechanism by which milk is transported from the breast alveoli to the nipple.
Suckling by the baby stimulates the paraventricular nuclei and supraoptic nucleus in the hypothalamus, which signals to the posterior pituitary gland to produce oxytocin. Oxytocin stimulates contraction of the myoepithelial cells surrounding the alveoli, which already hold milk. The increased pressure causes milk to flow through the duct system and be released through the nipple. This response can be conditioned e.g. to the cry of the baby. Milk ejection is initiated in the mother s breast by the act of suckling by the baby.
The milk ejection reflex (also called let-down reflex) is not always consistent, especially at first. Once a woman is conditioned to nursing, let-down can be triggered by a variety of stimuli, including the sound of any baby. Even thinking about breastfeeding can stimulate this reflex, causing unwanted leakage, or both breasts may give out milk when an infant is feeding from one breast. However, this and other problems often settle after two weeks of feeding. Stress or anxiety can cause difficulties with breastfeeding. The release of the hormone oxytocin leads to the milk ejection or let-down reflex.
Oxytocin stimulates the muscles surrounding the breast to squeeze out the milk. Breastfeeding mothers describe the sensation differently. Some feel a slight tingling, others feel immense amounts of pressure or slight pain/discomfort, and still others do not feel anything different. A poor milk ejection reflex can be due to sore or cracked nipples, separation from the infant, a history of breast surgery, or tissue damage from prior breast trauma.
If a mother has trouble breastfeeding, different methods of assisting the milk ejection reflex may help. These include feeding in a familiar and comfortable location, massage of the breast or back, or warming the breast with a cloth or shower. Milk ejection reflex mechanism [ edit ] This is the mechanism by which milk is transported from the breast alveoli to the nipple. Suckling by the baby innervates slowly-adapting  and rapidly-adapting  mechanoreceptors that are densely packed around the areolar region.
The electrical impulse follows the spinothalamic tract, which begins by innervation of fourth intercostal nerves. The electrical impulse then ascends the posterolateral tract for one or two vertebral levels and synapses with second-order neurons, called tract cells, in the posterior dorsal horn. The tract cells then decussate via the anterior white commissure to the anterolateral corner and ascend to the supraoptic nucleus and paraventricular nucleus in the hypothalamus, where they synapse with oxytocinergic third-order neurons.
The somas of these neurons are located in the hypothalamus, but their axon and axon terminals are located in the infundibulum and pars nervosa of the posterior pituitary, respectively. The oxytocin is produced in the neuron s somas in the supraoptic and paraventricular nuclei, and then is transported down the infundibulum via the hypothalamo-neurohypophyseal tract with the help of the carrier protein, neurophysin I, to the pars nervosa of the posterior pituitary, and then stored in Herring bodies, where they are stored until the synapse between second- and third-order neurons. Following the electrical impulse, oxytocin is released into the bloodstream. Through the bloodstream, oxytocin makes its way to myoepithelial cells, which lie between the extracellualr matrix and luminal epithelial cells that also make up the alveoli in breast tissue.
When oxytocin binds to the myoepithelial cells, the cells contract. The increased intra-aveolar pressure forces milk into the lactiferous sinuses, into the lactiferous ducts (a study found that lactiferous sinuses may not exist.  If this is true then milk simply enters the lactiferous ducts), and then out the nipple. Afterpains [ edit ] A surge of oxytocin also causes the uterus to contract. During breastfeeding, mothers may feel these contractions as afterpains.
These may range from period-like cramps to strong labour-like contractions and can be more severe with second and subsequent babies.   Without pregnancy, induced lactation, relactation [ edit ] In humans, induced lactation and relactation have been observed frequently in some cultures, and demonstrated with varying success in adoptive mothers. It appears plausible that the possibility of lactation in women (or females of other species) who are not biological mothers does confer an evolutionary advantage, especially in groups with high maternal mortality and tight social bonds.
  The phenomenon has been also observed in most primates, in some lemurs, and in dwarf mongooses.   Lactation can be induced in humans by a combination of physical and psychological stimulation, by drugs, or by a combination of those methods.  Some couples may stimulate lactation outside of pregnancy for sexual purposes. Rare accounts of male lactation (as distinct from galactorrhea) exist in historical medical and anthropological literature, although the phenomenon has not been confirmed by more recent literature.  Evolution [ edit ] Further information: Mammary gland § Evolution Charles Darwin recognized that mammary glands seemed to have developed specifically from cutaneous glands, and hypothesized that they evolved from glands in brood pouches of fish, where they would provide nourishment for eggs.  The latter aspect of his hypothesis has not been confirmed; however, more recently the same mechanism has been postulated for early synapsids.
 The discus fish ( Symphysodon aequifasciata) is known for (biparentally) feeding their offspring by epidermal mucus secretion.  A closer examination reveals that, as in mammals, the secretion of the discus fish s nourishing fluid may be controlled by prolactin.  As all mammals lactate, lactation must have evolved before the last common ancestor of all mammals, which places it at a minimum in the Middle or Late Triassic when monotremes diverged from therians . O. T. Oftedal has argued that therapsids evolved a proto-lacteal fluid in order to keep eggs moist, an adaption necessitated due to diapsids parchment shelled eggs which are more vulnerable to evaporation and dehydration than the mineralized eggs produced by some sauropsids  .
This protolacteal fluid became a complex, nutrient-rich milk which then allowed a decline in egg size by reducing the dependence on a large yolk in the egg.  The evolution of lactation is also believed to have resulted in the more complex dentition seen in mammals, as lactation would have allowed the prolonged development of the jaw before the eruption of teeth . During early evolution of lactation, the secretion of milk was through pilosebaceous glands on mammary patches, analogous to the areola, and hairs on this patch transported the nourishing fluids to the eggs as is seen in marsupials . Later the development of the nipple rendered mammary hairs obsolete.  Another well known example of nourishing young with secretions of glands is the crop milk of columbiform birds. Like in mammals and disc fish, this also appears to be directed by prolactin.
 Other birds such as flamingos and penguins utilize similar feeding techniques.  Lactation is also the hallmark of adenotrophic viviparity - a breeding mechanism developed by some insects, most notably tsetse flies. The single egg of the tse-tse develops into a larva inside the uterus where it is fed by a milky substance secreted by a milk gland inside the uterus.
 The cockroach species Diploptera punctata is also known to feed their offspring by milky secretions.  See also [ edit ] Lactation room Galactogogue Milk line Udder Breastfeeding Lactation failure Lactation suppression Erotic lactation References [ edit ] ^ a b Capuco, A. V.; Akers, R. M. (2009).
The origin and evolution of lactation. Journal of Biology. 8 (4): 37. doi: 10.1186/jbiol139.
PMC 2688910. PMID 19439024. ^ McNeilly, A. S.
(1997). Lactation and fertility. Journal of Mammary Gland Biology and Neoplasia. 2 (3): 291–298. doi: 10.1023/A:1026340606252. PMID 10882312.
^ a b c Mohrbacher, Nancy; Stock, Julie (2003). The Breastfeeding Answer Book (3rd ed. (revised) ed.). La Leche League International. ISBN 0-912500-92-1.
^ Cregan M, Mitoulas L, Hartmann P; Mitoulas; Hartmann (2002). Milk prolactin, feed volume and duration between feeds in women breastfeeding their full-term infants over a 24 h period. Exp Physiol. 87 (2): 207–14. doi: 10.1113/eph8702327. PMID 11856965.
CS1 maint: Multiple names: authors list ( link) ^ Sears, Martha; Sears, William (2000). The Breastfeeding Book. Little, Brown. ISBN 978-0316779241. ^ deCarvalho M, Anderson D, Giangreco A, Pittard W; Anderson; Giangreco; Pittard Wb (1985).
Frequency of milk expression and milk production by mothers of non-nursing premature neonates. Am J Dis Child. 139 (5): 483–5. doi: 10.1001/archpedi.1985.02140070057033. PMID 3984973.
CS1 maint: Multiple names: authors list ( link) ^ Hopkinson J, Schanler R, Garza C; Schanler; Garza (1988). Milk production by mothers of premature infants. Pediatrics.
81 (6): 815–20. PMID 3368280. CS1 maint: Multiple names: authors list ( link) ^ Daly S, Owens R, Hartmann P; Owens; Hartmann (1993). The short-term synthesis and infant-regulated removal of milk in lactating women. Exp Physiol. 78 (2): 209–20.
PMID 8471241. CS1 maint: Multiple names: authors list ( link) ^ Grachev, I.; Alekseev, N.; Velling, V. (1977). Slowly-adapting mechanoreceptor units of the guinea pig mammary nipple. Fiziol Zh SSSR Im I M Sechenova.
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Properties of the mechanoreceptors of the nipple of the guinea pig mammary gland. (Rapidly adapting mechanoreceptor units). Fiziol Zh SSSR Im I M Sechenova.
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Lactation - Wikipedia
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